Premier Inn do wetrooms for accessibiliy, which work well. I think it's clear on their site which locations have this, though I haven't looked for a while.
This was the first thing that came to my mind when i was working at a pub years ago and they converted a building to accommodation - one having a huge accessible wet room.
You can really go to town & not worry about cleanup
Premier inn or Travelodge. Book an accessible room which has a wet room. Absolutely brilliant for space and lots of room to lay on the floor wet and messy then clean up is really easy too