I don't have it, but it was Season 2, episode 64, which aired on 12/6/11. Was a really good hit but Melissa Gilbert was pissed off because she couldn't see anything afterwards.
It was a pretty good pieing, certainly better than the one her sister got on the same show. Melissa was NOT happy about it, although you couldn't really tell that from the original broadcast, where it appeared she was a good sport about it. She jokingly threatened revenge on Julie Chen, which sadly never happened (as far as I know anyway). However, I remember Melissa complaining about it quite a bit on some other talk show, saying it was a really mean pieing and that Julie did it too hard or held the pie in her face for too long or something along those lines.
The Melissa Gilbert pieing from above mysteriously disappeared from the Internet at some point. Not sure why or how, but all versions of it seem to have been scrubbed from YouTube. Ditto with the Kelly Ripa "Rock, Paper, Scissors, Pie" clip from Fallon. (There are plenty of other messy clips of Ripa available for viewing, including a different one with Fallon, but I think that's on her show, not his.)